Create a few custom keyboard shortcuts for your most used tools or commands. Not too many, otherwise its hard to remember all of them.
I had problems with overlapping Markups. Therefore I use F1 to hide all markups with a single button, even while using different tools, without anything in the way.
After completing the markup it´s also hidden. Don´t fortget that 😁.
For example "F1" to "Hide Markups" (all Markups) or "Hide" (single Markup´s)